Up to 17% weight loss
GLP-1
Semaglutide
Lose up to 17% with our Wegovy weight loss service
Sourced directly from manufacturer Novo Nordisk
Supported by UK-based clinical expertise and monthly check-ins
No hidden fees (pay-as-you-go)
Be the first to know when GLP-1 weight loss tablets are available
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What are Wegovy tablets?
Wegovy tablets contain semaglutide, the same active ingredient as the Wegovy injection, and work by mimicking a natural hormone that signals to your brain when you're full, helping to reduce appetite and how much you eat.
The key difference from the injection is simply that the tablet is taken once-daily instead of a once-weekly injection. The tablet of course means no needles and there is also no refrigeration required.
Wegovy tablets were approved by the FDA in December 2025 and became available in the US from January 2026. UK approval is expected later in 2026, subject to review by the MHRA. Phlo Clinic will offer them as soon as they become available.
What are they?
Tablet-based weight loss treatments
Contain a GLP-1 receptor agonist (the same active ingredient as Wegovy)
Taken once daily orally, rather than once weekly by injection
Clinically tested with results comparable to injectable options
Why are people interested?
A non-injectable alternative for those who prefer not to use a pen
Easier to fit into everyday life for some people
No refrigeration or injection equipment required
The same clinically-led approach, in a simpler format
How effective are Wegovy tablets?
What the evidence shows
In the OASIS 4 phase 3 trial (a 64-week study of 307 adults with obesity or overweight) people taking Wegovy tablets lost an average of 13.6% of their body weight, compared to 2.2% on placebo. Results were comparable to those seen with the Wegovy injection in earlier trials, suggesting the tablet delivers similar clinical benefit despite the different delivery method.
13.6%
average body weight lost over 64 weeks
60%
of patients lost at least 10% of body weight
28%
of patients lost at least 20% of body weight
*These are averages from a controlled clinical setting alongside a reduced-calorie diet and increased physical activity — individual results will vary.
Source - Wharton S, et al. Oral semaglutide 25mg in adults with overweight or obesity (OASIS 4). N Engl J Med. 2025;393(11):1077–1087.
* Averages from clinical trials in controlled settings alongside diet and lifestyle support. Individual results will vary.
* The two trials used different designs and durations and cannot be directly compared with each other.
* Both treatments are not yet available in the UK. Availability is subject to regulatory approval. Both expected in 2026.
Are Wegovy tablets safe to take?
Wegovy tablets have a well-established safety profile, consistent with semaglutide in its injectable form, which has been used by millions of patients worldwide. In the OASIS 4 trial, serious adverse events were actually less common in the treatment group than in the placebo group (3.9% vs 8.8%), and fewer than 7% of patients stopped treatment due to side effects.
As with any prescription medicine, Wegovy tablets are not suitable for everyone. They should not be taken by people with a personal or family history of medullary thyroid cancer or MEN2, and are not currently approved for use during pregnancy. Our clinical team will assess your suitability before any prescription is issued.
Clinically tested - approved by the FDA following a phase 3 randomised controlled trial
Side effects are mostly mild - the most common are nausea and vomiting, typically during dose escalation, and settling down over time for most patients
Prescriber-led at Phlo Clinic - our clinicians will review your health history before prescribing and monitor you throughout treatment
Join our waitlist to be notified as soon as Wegovy tablets are available at Phlo Clinic
Wegovy tablets are not yet available in the UK but that is soon to change. When approved, they will only be available on prescription following a clinical assessment.
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Wegovy tablets vs injections: what are the key differences?
Oral GLP-1 tablets and injectable GLP-1 treatments are both effective, clinically-proven options. The right choice depends on your personal preferences and circumstances. Here is a quick comparison:
* Averages from clinical trials in controlled settings alongside diet and lifestyle support. Individual results will vary.
* The two trials used different designs and durations and cannot be directly compared with each other.
* Both treatments are not yet available in the UK. Availability is subject to regulatory approval. Both expected in 2026.
If you are ready to start your weight loss journey today...
our injectable Wegovy treatment is available now with full clinical support from the Phlo Clinic team.
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Explore injectable Wegovy
What does the Wegovy tablet dosage guide look like?
Wegovy tablets follow a gradual four-step titration schedule, starting at a low dose of 1.5mg daily and increasing at a minimum every four weeks, giving your body time to adjust and helping to minimise digestive side effects like nausea. The full maintenance dose of 25mg once daily is typically reached by week 16 of treatment if you respond well, and is taken long-term to maintain weight loss results.
The tablet is taken once daily on an empty stomach, with a small amount of water, followed by a 30-minute wait before eating, drinking anything other than water, or taking other oral medicines. This fasting window is important for the medication to absorb properly.
Recommended dosage schedule
1.5mg
Once daily
Days 1-30
4mg
Once daily
Days 31-60
9mg
Once daily
Days 61-90
25mg
Once daily
Day 91 onwards
Standard Wegovy dosing schedule
| Phase | Daily dose | Duration |
|---|---|---|
Step 1 |
1.5mg
once daily |
Weeks 1-4 |
Step 2 |
3mg
once daily |
Weeks 5-8 |
Step 3 |
7mg
once daily |
Weeks 9-12 |
Step 4 |
25mg
once daily |
Week 13 onwards |
What to expect
Step 1
Your body begins adjusting to semaglutide. Mild nausea is common during this phase and usually settles quickly.
Step 2
Appetite begins to reduce noticeably for most patients. Continue taking on an empty stomach each morning.
Step 3
Weight loss typically becomes more consistent at this stage. Side effects, if any, are usually milder than in earlier weeks.
Step 4
Full therapeutic dose for ongoing weight management. This is the dose used throughout the OASIS 4 clinical trial, in which patients lost an average of 13.6% of body weight.
The schedule above is based on the FDA-approved US prescribing information. Guidance will be confirmed by the MHRA on approval. Always follow the dosage instructions provided by your Phlo Clinic clinician and do not adjust your dose without speaking to a healthcare professional first.
Source: Novo Nordisk. Wegovy (semaglutide) tablet US prescribing information, 2026. Titration schedule based on FDA-approved labelling. UK dosing may vary subject to MHRA guidance.
How to take your Wegovy tablet
Daily routine
Take first thing in the morning on an empty stomach, before eating or drinking anything other than water
Use a small amount of water, no more than around 120ml (4oz); do not take with other drinks
Wait 30 minutes before eating, drinking anything else, or taking other oral medicines; this allows the semaglutide to absorb properly
If you miss a dose, skip it and take your next tablet at the usual time the following day; do not take two doses to make up for a missed one
Already on Wegovy injections?
If you're currently taking Wegovy 2.4mg injections and want to switch to the tablet, you may be able to start at the full 25mg maintenance dose, skipping the titration steps entirely.
This would typically begin one week after your last injection, however is subject to a clinical review. One of our prescribers will assess your suitability as part of a switching consultation.
Why join the waitlist for Wegovy tablets with Phlo Clinic?
We'll take care of the waiting so you don't have to. Here's what signing up means in practice.
Be the first to know: get notified the moment Wegovy GLP-1 tablets are available with Phlo Clinic
Clinician-led care: as with all Phlo Clinic treatments, you will receive ongoing support from our UK-registered clinical team
No need to keep checking: we will do the monitoring and reach out when there is a meaningful update
Trusted by thousands of patients: Phlo Clinic is a CQC-registered provider and GPhC-regulated pharmacy
Expert guidance: our clinicians will help you understand whether oral GLP-1 treatment is right for you when it becomes available
Interested in Wegovy oral tablets?
Don't forget to join our waitlist to be notified as soon as Wegovy tablets are available at Phlo Clinic
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Join the waitlist
Wegovy tablets side effects
The side effect profile of Wegovy tablets is broadly consistent with the Wegovy injection, most commonly affecting the digestive system, particularly in the early weeks of treatment while your dose is being increased. For the majority of patients, these effects are mild to moderate and improve as the body adjusts.
The following side effects were reported in the OASIS 4 phase 3 clinical trial:
Nausea
The most commonly reported side effect, affecting around 47% of patients taking the tablet
Vomiting
Reported in around 31% of patients, most often when increasing dose
Diarrhoea
A known effect across the GLP-1 class, generally mild and short-lived
Constipation
Reported by some patients, particularly earlier in treatment
Pancreatitis
Rare but serious; seek urgent medical attention if you experience persistent severe abdominal pain
Gallbladder problems
Including gallstones, consistent with other GLP-1 medicines
Thyroid tumours
A precautionary warning on the box; do not take if you have a personal or family history of medullary thyroid cancer or MEN2. This was not observed in animal studies, but human relevance is unknown
How do side effects compare to Wegovy injections?
The types of side effects are largely the same. Both are semaglutide and act on the same pathways.
The main practical difference is in how side effects are managed: the tablet requires a strict fasting protocol (taken on an empty stomach, with a 30-minute wait before eating & drinking), and nausea rates in the tablet trial were somewhat higher than those reported in injectable Wegovy trials.
However, serious adverse events were less common with the tablet in the OASIS 4 trial than with placebo.
Side effects of tablets vs injection
How do the two treatments' side effects vary?
~14–17% weight loss
Wegovy Tablet
Oral Semaglutide (25mg)
Nausea in ~47% of patients
Vomiting in ~31% of patients
Must be taken fasted, 30-min wait
No injection site reactions
Serious adverse events: 3.9%
Coming soon - join the waitlist
~20.7% weight loss
Wegovy FlexTouch Pen
Injectable Semaglutide (2.4mg)
Nausea in ~44% of patients
Vomiting in ~24% of patients
No fasting requirement
Possible injection site reactions
Serious adverse events: similar class profile
Available now
Will I be able to switch from Wegovy injections to Wegovy tablets?
If you're currently taking Wegovy injections and would like to switch to the tablet, this will be possible but it will require a clinical review to make sure the switch is appropriate for you and that any dose transition is managed safely.
The tablet is not simply a like-for-like swap: the dosing is different (25mg oral vs 2.4mg injectable), the fasting requirements are new, and your clinician will want to ensure you're stable on your current dose before any change is made.
At Phlo Clinic, the switching process would follow these steps:
Join the waitlist
Register your interest now. We'll notify you the moment Wegovy tablets are available to prescribe and when you can start your consultation to make the switch.Complete a switching consultation
One of our prescribing pharmacists will review your treatment history, current dose, and health profile to confirm you're a suitable candidate to switch.Receive your prescription
If approved, your clinician will prescribe Wegovy tablets at the appropriate starting dose for a switch. Please note, this may differ from your current injection dose.Begin your tablet treatment
We'll guide you through how to take the tablet, how to manage side effects, dose escalation schedule, and provide monthly check-ins as well as support via our patient care team, 7 days a week.
Want to learn more about Wegovy tablets?
We've put together a set of articles and answers to the questions our patients are asking most. Whether you're weighing up your options, already on Wegovy injections, or just getting started with your research, these are a good place to begin.
What happens after you register?
You will receive a confirmation that we have your details
We will email you when oral GLP-1 tablets are available with Phlo Clinic or when there is a significant regulatory update
In the meantime, our clinical team are on hand if you have any questions about your weight loss options
If you decide you would like to start treatment now, you can begin a free online assessment for injectable Wegovy or Mounjaro at any time
Wegovy FAQs
Is there a Wegovy tablet available in the UK?
Can I buy oral Wegovy in the UK?
What is oral semaglutide?
How much would a Wegovy pill cost in the UK?
Why are people searching for a Wegovy pill?
Can I join a waiting list for Wegovy tablets?
What can I do while waiting for a Wegovy tablet?
Can I switch from Wegovy injections to tablets?
How can we help
