Starting Wegovy (semaglutide) can feel like a big step toward managing your weight and improving your overall health. Knowing what to expect during your first dose can help you feel more confident and prepared. This guide covers how to take your first injection safely and how to manage early side effects.
What is Wegovy (Semaglutide)?
Wegovy is a GLP-1 receptor agonist, a medication that mimics a natural hormone called GLP-1. This hormone helps control appetite, slow digestion, and regulate blood glucose.
Wegovy is FDA-approved for weight management in adults with obesity or those who are overweight and have related health conditions. It helps you feel satisfied after smaller meals, making it easier to maintain long-term weight loss.
What is the Wegovy starting dose?
Your first dose of Wegovy is typically 0.25 mg once weekly, given as a subcutaneous injection.
This starting amount helps your body get used to the medicine gently. Over several months, you may increase your dose step-by-step to reach the most effective level for weight loss. This titration process begins with the lowest dose to minimize side effects.
When to Expect Weight Changes
During the first week, any weight change is often temporary water fluctuation. Measurable weight loss usually starts after 1–2 weeks once your body is used to the medication. Remember, the first dose of Wegovy is mainly an introduction—slow, steady progress is key.
What to know before your first injection
Before you begin, there are a few instructions to follow to ensure your Wegovy pen is ready for use:
- Storage: Keep your Wegovy pen refrigerated (between 2°C to 8°C).
- Before use: Allow it to warm to room temperature for about 30 minutes.
- Supplies: Have alcohol wipes and a sharps bin nearby.
- Injection site: You can inject into your abdomen, thigh, or upper arm—whichever feels most comfortable. Be sure to rotate sites each week to reduce the risk of irritation or discomfort.
How to inject Wegovy safely
- Wash your hands and clean your chosen site with an alcohol wipe.
- Check that the medicine is clear and colourless.
- Prepare your pen: remove the cap, attach a new needle and prime by turning the dial, hold the pen needle-up, tap out any air bubbles, and press the knob to release a tiny drop of medicine.
- Set your dose: turn the dial to your prescribed amount.
- Hold the pen against your skin and press the injection button.
- Hold in place for the recommended few seconds to make sure the full dose is delivered.
- Safely dispose of the used pen in your sharps container.
For more information, check out our video guide below on how to administer Wegovy
Common Wegovy side effects after your first dose
It’s normal to feel some early changes, including:
- Mild nausea or stomach bloating
- Reduced appetite and feeling full faster
- Slight changes in thirst or bowel habits
- Occasionally, mild tiredness or headaches
These effects are common, usually mild and settle quickly.
What changes to expect in the first week of Wegovy?
- Some people notice improved blood sugar control after the first few doses.
- Appetite changes typically appear by day 2 or 3.
- Side effects, if they happen, tend to peak between 24–72 hours then ease off.
Wegovy first dose FAQs
Can I take other medications whilst on my first dose?
Always tell your healthcare provider about any other medicines or supplements you use. Wegovy can interact with some drugs that may affect blood glucose or digestion, so adjustments to dosing or timing may be needed for your safety.
For more details, explore our blog post on common drug interactions with Wegovy.
Can I drink alcohol after my first Wegovy dose?
While alcohol isn’t strictly off-limits, it can:
- Interfere with blood sugar control
- Worsen nausea or dehydration
- Reduce your energy or appetite
- Add empty calories that slow progress
Limiting or avoiding alcohol, especially during your first few doses, is a good idea.
Can I exercise after my first Wegovy dose?
Mild exercise is encouraged, but during your first week:
- Start with gentle activity like walking or stretching.
- Avoid intense workouts if you feel tired or nauseated.
- Gradually increase your activity as your body adjusts.
When should I contact a Healthcare Provider?
Reach out promptly if you experience:
- Severe or persistent nausea or vomiting
- Signs of an allergic reaction: swelling, rash, difficulty breathing
- Severe abdominal pain or side effects that don’t improve
- Concerns about blood sugar or dose adjustments
- If you have any concerns or questions about next steps in the titration process
Your first Wegovy dose is the start of an exciting journey toward better health. It’s normal to take a few weeks to adjust. Be patient, listen to your body, and reach out to the Phlo Clinic team with any concerns—we’re here to guide and support you every step of the way.
.png)