Medications like Wegovy can be extremely effective for weight loss, but like any medication, allergic reactions to Wegovy can occur. Understanding the signs of a potential allergic reaction can help you seek prompt medical attention when required and ensure your weight loss journey remains safe and effective.

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Common signs you may be allergic to Wegovy

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An allergic reaction occurs when the immune system mistakenly identifies a normally harmless substance as a threat. In response the body releases chemicals such as histamine to try to defend itself which can lead to symptoms like itching, swelling, rashes or breathing difficulties.

Wegovy itself is unlikely to cause an immune reaction as it closely resembles a natural human hormone (GLP 1). Therefore, most reactions arise from sensitivity to other components in the pen such as preservatives or the needle material.

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How to manage skin sensitivity while on Wegovy

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Injection site reactions are a relatively common side effect when using Wegovy, affecting up to 1 in 10 people. After an injection you may notice mild redness, itching, swelling, bruising, or tenderness around the area. These symptoms usually appear shortly after the injection and typically settle within a day or two as your body adjusts.

There are also a few simple steps that can help minimise discomfort:

• Rotate your injection site each week. You can self-inject into your stomach or thigh areas or have someone else inject it into the back of your upper arm.
• Use a cold compress before the injection to numb the area or afterwards to help reduce inflammation and soreness.
• Consider an antihistamine or topical cream if itching occurs. Your local pharmacist can advise on suitable options.
• Prepare the area properly. Make sure the skin is clean before injecting and always use a new, straight needle for each dose.

If the reaction is getting worse, spreading, becoming more red or the pain is not tolerable please stop using your injection and seek medical attention.

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What to do if you suspect a severe allergy?

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A severe allergic reaction usually presents very differently from a mild injection site reaction. The symptoms tend to appear suddenly and may affect multiple parts of the body. Warning signs to look out for include:

• Sudden hives or raised, itchy welts on the skin
• Swelling of the face, lips, tongue or throat
• Wheezing, shortness of breath or chest tightness
• Dizziness, fainting or a feeling of pressure in the chest

If you experience any of these symptoms stop using the injection immediately and seek urgent medical attention. These symptoms may indicate anaphylaxis - a serious allergic reaction that requires prompt medical treatment. Even if symptoms start to improve, it is important to get medical attention as soon as possible.

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It’s completely understandable to feel anxious about the possibility of an allergic reaction especially when starting an injectable medication. At Phlo Clinic, you can speak to our team before beginning treatment with Wegovy. They can help you understand which reactions are common, what to look out for and when it’s important to seek medical advice so you can start treatment feeling informed and confident.

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References

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Wegovy 0.25 mg, FlexTouch solution for injection in pre-filled pen. Wegovy 0.25 mg, FlexTouch solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (emc) | 13799.

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