Mounjaro and tiredness: How to manage fatigue and low energy

Last reviewed
June 19, 2025
Reviewed by
Hazel Shore
Next review
June 18, 2026
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Tiredness is a common side effect some people experience when starting Mounjaro. This blog explores why fatigue can occur and offers simple, practical tips to manage energy levels while continuing your progress on treatment.

If you’re taking Mounjaro (Tirzepatide) and finding yourself feeling more tired than usual, you're not imagining it. Fatigue is a side effect that some people experience, particularly in the early weeks as your body adjusts to the medication and eating habits begin to change.

 

Is Mounjaro linked to fatigue?

There are a few reasons this tiredness can happen. Reduced calorie intake, blood glucose fluctuations, changes to your digestion, and even mild dehydration can all contribute. But the good news? There are simple, sustainable ways to support your energy levels while staying on track with your goals.

How to manage tiredness while taking Mounjaro

1. Prioritise good-quality sleep

When your body’s adjusting, rest becomes even more important. Try to get 7–9 hours of sleep each night. Establishing a consistent sleep schedule (going to bed and waking up at the same time each day) can help regulate your internal clock and improve sleep quality.

2. Create a calming bedtime routine

Small changes like switching off screens an hour before bed, keeping your room cool and dark, and winding down with a book or a warm shower can make a real difference.

3. Eat balanced, nutrient-rich meals

Even if your appetite is reduced, your body still needs fuel. Focus on whole foods, lean proteins, and slow-release carbs to give your body the energy it needs. Ultra-processed foods or skipping meals entirely can lead to energy crashes and increased fatigue.

4. Get morning light exposure

Natural light in the morning can help regulate your circadian rhythm and support energy levels throughout the day. A short walk outside or even sitting near a bright window can help.

How to reduce tiredness whilst taking Mounjaro

1. Cut back on caffeine and screen time

Too much caffeine (especially in the afternoon) or too much time on screens before bed can interfere with sleep, which may leave you more tired the next day.

2. Stay hydrated

Fatigue is a common symptom of mild dehydration. Aim to drink around 2-3 litres of fluid a day. Carrying a water bottle with you is an easy way to stay on track.

3. Move your body gently

While it might seem counterintuitive, light physical activity like walking or stretching can actually boost your energy and improve your sleep. Start small and listen to your body. Pacing yourself is key.

Key takeaway

Feeling more tired than usual on Mounjaro is something some people experience, especially early on, but there are lots of simple ways to support your energy. Prioritising rest, eating well, staying hydrated, and finding a daily rhythm that works for you can all help you feel more balanced.

Pay attention to how your body responds. If fatigue continues or gets worse over time, it’s a good idea to speak to your healthcare provider to rule out any other causes and make sure everything’s on track.

Remember, managing your energy is an important part of looking after your overall wellbeing - not just your weight.

Want to learn how to boost your energy levels while on Mounjaro? Read our blog on how to manage tiredness with simple, yet effective tips.

Want to learn more? Visit our advice hub

Find out more about Mounjaro and it's side effects in our advice hub

Created & reviewed by:
Hazel Shore
|
Obesity Specialist Dietitian
Last reviewed:
June 19, 2025
Next review:
June 18, 2026
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