Mounjaro side effects: Constipation & diarrhoea

Last reviewed
April 14, 2025
Reviewed by
Hazel Shore
Next review
April 13, 2026
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If you've recently started Mounjaro and are experiencing either constipation or diarrhoea, you're not alone. These are common side effects, especially in the early stages of treatment or when increasing your dose. While they can be uncomfortable, there are effective ways to manage them.

In this guide, we'll explain why Mounjaro can cause constipation and diarrhoea, and provide practical tips to help alleviate these symptoms. For a full overview of all potential side effects, be sure to checkout our Mounjaro Side Effects Guide.

Does Mounjaro cause constipation?

Constipation is a known side effect of Mounjaro, although in clinical trials, only about 2.5% of participants experienced it. One of the effects of Mounjaro is that it can slow down the digestive process, which may contribute to constipation.

What can I do to help with constipation on Mounjaro?

Here are several dietary and lifestyle strategies that may help reduce constipation and diarrhoea and are worth trying first.

Stay hydrated

Dehydration can make stools harder and more difficult to pass. Drinking plenty of water helps soften stools—aim for 2-3 litres per day.

Increase fibre intake

Consuming high-fibre foods like vegetables, fruits, and whole grains can support regular bowel movements. Gradually increase your fibre intake to prevent gastrointestinal discomfort.

Physical activity

Regular movement, like walking or light exercise, helps stimulate digestion and support regular bowel movements.

Consider a stool softener or laxative

If adjusting hydration and diet doesn’t provide relief, consult with Phlo Clinic for advice on appropriate stool softeners.

Does Mounjaro cause diarrhoea?

In clinical trials, about 16% of patients reported experiencing diarrhoea, which is more common than constipation. Mounjaro works by altering the digestive processes, including gut motility, which can lead to changes in digestion. For some people, this can result in looser stools or diarrhoea.

  

What can I do to help with diarrhoea on Mounjaro?

Here are several steps you can take to help ease symptoms.

Stay hydrated

Diarrhoea can cause fluid loss, leading to dehydration. Drinking plenty of fluids, along with electrolyte drinks or bone broth, can help replenish lost fluids.

Eat easily digestible foods

Certain foods can irritate the digestive system and worsen diarrhoea. Choose easy-to-digest options like toast, bananas, applesauce, and rice. Avoid spicy, fatty, or greasy foods.

Eat small, frequent meals

Smaller meals are easier to digest and may help alleviate diarrhoea.

If diarrhoea persists, you may require anti-diarrhoea medication, oral rehydration solution or an adjustment to your Mounjaro dosage.

 

For further assistance, please reach out to Phlo Clinic. Our team of Pharmacists is here to help you manage your symptoms and provide personalised guidance.

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Created & reviewed by:
Hazel Shore
|
Obesity Specialist Dietitian
Last reviewed:
April 14, 2025
Next review:
April 13, 2026
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